2 edition of regulation of the adipose tissue mass found in the catalog.
regulation of the adipose tissue mass
International Meeting of Endocrinologists, 4th, Marseille, 1973
|Series||Excerpta medica international congress series -- no. 315, International congress series -- no. 315|
|Contributions||Boyer, J., Vague, Jean|
|LC Classifications||RC628 I5 1973|
|The Physical Object|
|Number of Pages||360|
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Moreover, IL6 acts on adipose tissue to increase leptin secretion and suppress satiety, and IL6 increases adipose tissue lipolysis, which, in turn, promotes hepatic gluconeogenesis and hepatic insulin resistance (9, 10).
IL6 also increases the loss of adipose tissue following exercise and in response to cancer by: 1. Nowadays, adipose tissue is not only regarded as an organ of storage related to fuel metabolism but also as an endocrine organ involved in the regulation of insulin sensitivity, lipids and energy metabolism.
These proceedings cover the nervous regulation of both white and brown adipose tissue : Hardcover. IL6 Signaling Differentially Regulates Adipose Tissue Inflammation.
Our studies of macrophage and adipocyte IL6 deficiency lead to opposite conclusions concerning the role of IL6 in adipose tissue inflammation and metabolic syndrome.
We show that adipocyte IL6 is required for ATM accumulation, but causes only modest changes in insulin by: 1. The regulation of the adipose tissue mass: proceedings of the IV International Meeting of Endocrinology, Marseilles, JulyAuthor: Jean Vague ; Jean Louis Boyer ; G M Addison.
Neural and Hormonal Control of Adipose Tissue Metabolism During Exercise. There are several neural and hormone regulators of adipose tissue metabolism, which act in synergy to control the rate of fatty acids flux (essentially lipolysis) to meet the metabolic demands of the exercising by: Brown adipose tissue plays a critical role in neonatal thermogenesis, insuring survival of the newborn infant during the transition from intrauterine to extrauterine life.
In rodents, the generation and/or expansion of brown adipose tissue within white adipose depots (“beiging”) provides a defense against obesity and glucose by: 2. In rodents, the generation and/or expansion of brown adipose tissue within white adipose depots (“beiging”) provides a defense against obesity and glucose intolerance.
Overall, these observations directly implicate adipose tissue mass in the regulation of blood pressure. When compared with lean subjects with body mass index (BMI) ∼ 25, plasma AGT levels and blood pressure in humans were respectively increased by 22% and 15% in obese patients with BMI ∼ 40 (35).Cited by: Fig.
1 Adipose tissue (AT) plays a crucial role in the regulation of whole-body homeostasis via the synthesis and release of adipocyte-specific factors known as adipokines.
In addition to the role of adipose tissue as an endocrine organ, the results emphasize the autocrine/paracrine mechanisms which are postulated to play a role in adipose tissue development and Cited by: The greater the fat cell size and the adipose tissue mass, the greater is the contribution of adipose production to circulating PAI Experimental data show that visceral adipose tissue has a higher capacity to produce PAI-1 than subcutaneous adipose by: Lipolysis is a critical process to hydrolyze triglyceride in adipose tissue, thereby breaking down the stored lipid and maintaining energy homeostasis.
Recent studies have made significant progress in understanding the steps of lipolysis. This chapter discusses the major pathways that regulate lipolysis in adipose : Xin Li, Kai Sun. The production of new adipocytes is required to maintain adipose tissue mass and involves the proliferation and differentiation of adipocyte precursor cells (APCs).
In this review, we outline new developments in understanding the phenotype of APCs and provide evidence suggesting that APCs differ between distinct adipose tissue depots and are affected by obesity.
Post-mitotic mature adipocytes Cited by: In obesity, dysregulated metabolism and aberrant expansion of adipose tissue lead to the development of tissue hypoxia that plays an important role in contributing to obesity-associated metabolic disorders.
Recent studies utilizing adipocyte-specific hypoxia-inducible factor-α (HIF-α) gain- or loss-of-function animal models highlight the pivotal involvement of hypoxic responses in the Cited by: 9. Obesity and metabolic disorders such as insulin resistance and type 2 diabetes have become a major threat to public health globally.
The mechanisms that lead to insulin resistance in type 2 diabetes have not been well understood. In this study, we show that mice deficient in MAPK phosphatase 5 (MKP5) develop insulin resistance spontaneously at an early stage of life and glucose intolerance at Cited by: 9.
The rate-limiting step of adipose tissue lipolysis is the hydrolysis of triacylglycerol by hormone-sensitive lipase (HSL) (84 kDa) (9). The long-term regulatory mechanism of lipolysis by insulin, which is more relevant to type 2 diabetic patients, has not been well by: Effect of caloric restriction (CR) on the expression of beclin in the visceral adipose tissue of mice.
(a) Lean mice were fasted overnight and, at hours, chow was made freely available for 4 Cited by: Adipose tissue acts as an endocrine system organ by generating hormones that influence metabolic activity in other organ of the hormones produced by adipose cells influence sex hormone metabolism, blood pressure regulation, insulin sensitivity, fat storage and use, blood clotting, and cell signaling.
A major function of adipose cells is to increase the body's sensitivity Author: Regina Bailey. Adipose tissue, which is primarily composed of adipocytes as well as pre-adipocytes, macrophages, endothelial cells, fibroblasts, and leucocytes, has been increasingly recognized as a major player of systemically metabolic regulation.
As the fuel reservoir, adipose tissue conserves the heat of the body and controls the lipid mobilization. Alteration of adipose tissue mass in obesity increases the production of most adipose secreted factors; therefore white adipose tissue could play a key role in multiple metabolic disorders and in the increased risk of cardiovascular disease associated with obesity.
This paper will review the function and the regulation of adipocytokines in Cited by: Studies investigating the effects of exercise training on BAT mass and function have yielded conflicting data, and hence, is another area of intensive investigation.
This review will focus on studies aimed at elucidating the mechanisms regulating exercise training induced-adaptations to adipose by: Nowadays, adipose tissue is not only regarded as an organ of storage related to fuel metabolism but also as an endocrine organ involved in the regulation of insulin sensitivity, lipids and energy metabolism.
These proceedings cover the nervous regulation of both white and brown adipose tissue mass. Aims Insulin is a potent stimulator of adipose tissue lipoprotein lipase (LPL). Logically, the postprandial period is therefore a privileged time of the day for the regulation of LPL by insulin in this tissue.
It is not clear to what extent a defect such as insulin resistance could affect this regulation and contribute to postprandial, as well as fasting, by: Adipose tissue is located in several anatomical locations. These include subcutaneous adipose tissue, which is located under the skin and stores ~ 80% of total body fat with the major stores found in the upper (abdominal, subscapular fat) and lower body (gluteal–femoral fat).
Intraabdominal adipose tissues include the visceral adipose tissue located around the digestive organs (mesenteric. Identification of Novel Targets for Regulation of Adipose Tissue Mass The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U.S. Federal Government. Adipose tissue was at first characterized as a connective tissue that contained lipid droplets, without a link to the metabolism of the organism. After the discovery of adipose-derived serum factors, adipose tissue is now regarded as an endocrine organ at the center of energy homeostasis.
Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue e tissue is derived from : Expansion of subcutaneous adipose tissue by differentiation of new adipocytes has been linked to improvements in metabolic health.
However, an expandability limit has been observed wherein new adipocytes cannot be produced, the existing adipocytes become enlarged (hypertrophic) and lipids spill over into ectopic sites. Inappropriate ectopic storage of these surplus lipids in liver, muscle, and.
The ratio of adipose tissue/muscle LPL, which may be an important indicator of the tendency for storage of circulating lipids in adipose tissue, increased significantly after detraining. The adipose/muscle LPL ratio was +/- in the exercising runners, and +/- Cited by: This Special Issue, “Molecular Regulation of Exercise on Adipose Tissue and Related Diseases”, welcomes both original papers and review articles addressing updates on molecular and cellular targets of exercise to improve dysfunction of adipose tissue, which comprises various cell types.
The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord. ; 20(4) Björntorp P. The regulation of adipose tissue distribution is an important problem in view of the close epidemiological and metabolic associations between centralized fat.
•Key thermogenic tissue •Present in large amounts in the newborn-Helps offset heat loss that occurs after birth •Located along back, upper half of spine, and toward the shoulders •Tissue decreases as body grows and is mainly absent in adults •Multikicular with numerous small fat droplets •Cells are smaller than white adipose tissue.
Obesity is an established risk factor for hypertension. About 1 billion adults are overweight globally and numbers appear to be increasing. Stimulating endogenous activation of brown adipose tissue (BAT) mass that has unprecedented metabolic capacity can combat obesity, reverse insulin resistance and reduce comorbidities.
Renalase is a recently discovered flavin adenine dinucleotide (FAD Author: Manjunath Ramanjaneya. Regulation of Adipose Tissue Blood Flow in Humans (PhD thesis).
Oxford, UK: University of Oxford, Google Scholar; Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F. Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans.
Moreover, lean women can have as much body fat as obese men, so clearly relative adipose tissue mass is not the only consideration. In this review, we provide a synthesis of the current understanding of the acute and chronic impact of physical activity and exercise in the regulation of adipose tissue mass.
THE TRADITIONAL VIEW of adipose tissue as a passive reservoir for energy storage is no longer valid. As early asadipose tissue was identified as a major site for metabolism of sex steroids and production of adipsin, an endocrine factor that is markedly down-regulated in rodent obesity ().The subsequent identification and characterization of leptin in firmly established adipose Cited by: regulation of energy balance are the GI tract, liver and adipose tissue" Selected Answer: True Answers: True Fals e Question 4 0 out of 2 points Many institutionalized elderly patients have the syndrome of inappropriate secretion of antidiuretic hormone which may lead to Selected Answer: hypernatre mia Answers: hypernatre mia hyponatre mia.
Start studying Adipose Tissue. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. White Adipose (Unilocular) Tissue - Fat cells with single large lipid inclusion-Fatty tissue in humans -It's involved in the regulation of energy homeostasis and is secreted by adipocytes.
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.
Biochim Biophys Acta –, Crossref, Medline, Google Scholar; 58 Lumeng CN, Bodzin JL, and Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
J Clin Invest Cited by: Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. Feb 11;(6) doi: /pnas Epub Jan PMID: ; PMCID: PMC Link to article on publisher's siteCited by: 1.
As indicated above, leptin plays a major role in the regulation of appetite and energy balance and the circulating levels of leptin increases as adipose tissue mass increases. Leptin has also been shown to modulate T-cell function, thus demonstrating a pro-inflammatory role for leptin.
Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle.
Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have Cited by: